Complement fixation test for the diagnosis of Lyme disease.

Identification of Two Epitopes on the Outer Surface Protein A of the Lyme Disease Spirochete Borrelia burgdorferi

A murine IgM monoclonal antibody (MA-2C6) with κ-light chains directed against an antigenic determinant of outer surface protein A (OspA) of the Lyme disease spirochete, Borreliaburgdorferi, is produced. This antibody could bind specifically to OspA antigen of several isolates of B. burgdorferi, but not to the non-Lyme disease bacteria such as T. pallidum and B. hermsii. Antibody MA-2C6 was pur...

Report of a case of Lyme disease in Mazandaran

Lyme disease is caused by the spirochete Borrelia burgdorferi. Depending on the stage of illness, infection may be limited to the skin or involve the cardiac, nervous and musculoskeletal systems. Herein, we report a case of Lyme disease in a 23-year-old woman from North of Iran (Mazandaran) in early-localized stage of erythema chronicum migrans. The diagnosis was confirmed by the presence of se...

THE FIRST ENDEMIC CASE OF LYME BORRELIOSIS IN IRAN

This case report shows the existence of Lyme borreliosis disease in Iran and proves the existence of the spirochete Borrelia burgdorferi in Iran which had not been found before in the ticks of this region. It is important for our physicians to consider Lyme borreliosis in their differential diagnosis. Apart from skin manifestations, neurological, cardiac, articular and ocular lesions are no...

Indirect Complement Fixation in Foot-and-Mouth Disease

Indirect Complement Fixation in Foot and Mouth Disease. II. Screening of Cattle Serums